WEB TOOLS AND DATA MINING FOR MUSCLE SYSTEMS/OMICS DATA


William Duddy
Stephanie Duguez
Apostolos Malatras
Matthew Thorley
Lu Zhu


Our objectives lie in translational approaches for neuromuscular disorders, including Duchenne muscular dystrophy and motor neuron disease (Amyotrophic Lateral Sclerosis).

Some tools and resources are linked above, and some of our work is highlighted here in the image slider.

Contact us at if you would like to collaborate on any muscle bioinformatics challenges.
  1. CellWhere Nuc Acids Res 2015 43(W1):W571-5
  2. Exon skipping PLoS One 2015 10(3):e0120058
  3. Myofibre growth in DMD Skeletal Muscle 2015 5:16
  4. Systems analyses
  5. Muscle Gene Sets
    in transcriptomics
  6. Muscle Gene Set enrichment mapping
    Cell Rep. 2015 13(6):1172-82
  7. Interactomics and pathway analysis
  8. Genomic data visualization
  9. Data overlay on pathways
  10. Secretome & proteomic data analysis Cell Mol Life Sci 2013 70(12):2159-74

image slider made using ISM

SELECTED PUBLICATIONS

Muscle Gene Sets example 1 (hTERT immortalization): Thorley M et al. (2016) Skelet. Muscle 6(1):43

Muscle Gene Sets example 2 (ageing and SPRY1): Bigot A et al. (2015) Cell Rep. 13(6):1172-82

Networks and subcellular localization: Zhu L et al. (2015) Nucleic Acids Res. 43, W571–W575

Exon skipping drug design: Echigoya Y et al. (2015) PLoS One 10(3)

Myofibre growth in DMD murine model: Duddy W et al. (2015) Skelet. Muscle 5:16

Muscle systems analyses: Duguez S et al. (2013), Cell. Mol. Life Sci. 70(12):2159-74